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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
03/09/2011-07/09/2011
Istanbul, Turkey

ALTERATIONS IN RED BLOOD CELL RHEOLOGICAL PROPERTIES IN HEALTHY PERSONS LIVING AT LOW AND MID-ALTITUDES
Abstract number: PC232
Aydoan¹ Sami, Seda Artis¹ Ai[scedil]e, Basaran¹ Erdem, Dolu¹ Nazan
¹University of Erciyes, Medical Faculty, Department of Physiology, 38039, Kayseri, Turkey
Objective: 
After living at high altitude for a long time, the body begins to adapt to the oxygen shortage. The most important adaptation may be an increase in the number of red blood cells (RBC). On the other hand, in microcirculation, blood flow and adequate oxygen delivery to tissue are mainly dependent on RBC rheologic properties. In this study, the changes of hemorheological properties of two groups of healthy people who lived at low (1300 m) and mid (2300 m) altitudes were investigated.
Methods: 
Twenty-six healthy volunteers in each group were studied and hematologic and hemorheologic parameters were measured from blood samples. Hemoglobin (HGB), packed cell volume (PCV), RBCs, MCV, MCH and MCHC were measured by means of an electronic particle counter. Deformability of RBC was measured by Rheodyne SSD Laser Diffractometer. Aggregation measurements were done by Myrenne Aggregometer. RBC osmotic fragility was determined in a series tubes with increasing concentrations of NaCl solution by spectrophotometer and calculated as 50% hemolysis.
Results: 
RBC, HGB and PCV values were higher at mid altitudes than those at low altitudes. However, there were no significant differences in MCV, MCH and MCHC as red cell indices between two groups. In the other hands, as rheological parameters, erythrocyte deformability and osmotic fragility values were lower who lived at mid altitude compared to low altitude, but an increased were observed in RBC aggregation index (M1).
Conclusions: 
We conclude that especially hemorheological changes of red blood cells at different altitudes can be an important signal for high altitude diseases.
To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC232

Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
03/09/2011-07/09/2011
Istanbul, Turkey
EXERCISE-INDUCED ALTERATIONS IN HEMORHEOLOGICAL PARAMETERS IN SEDENTARY AND
EXERCISE-TRAINED INDIVIDUALS LIVING AT MID-ALTITUDE
Abstract number: PC233
Aydoan¹ Sami, Basaran¹ Erdem, Seda Artis¹ A., Dolu¹ Nazan
¹University of Erciyes, Medical Faculty, Department of Physiology, 38039, Kayseri, Turkey
Objective:
The effects of high altitude on humans are considerable, starting from as low as 1300 m above sea
level. Usually by 2000 m, they will experience more fatigue, and a greater potential for

dehydration.Altitude also affects individuals differently.The aim of this study was to investigate the
effects of moderate regular exercise on hematologic and blood rheologic properties on subjects who had been living at mid-altitude.
Methods:
Venous blood samples were obtained from 21 sedentary and 23 regularly trained male, who stayed for a long time at 2300 m.Hemoglobin (Hb), hematocrite, red blood cells (RBCs), MCV, MCH and MCHC were measured by using an electronic particle counter. RBC deformability was measured by Rheodyne SSD. Aggregation measurements were done by an aggregometer. Osmotic RBC fragility was determined in a series of NaCl solution by spectrophotometer.
Results: 
Hematological parameters (RBC, Hb, MCV, MCH and MCHC) and erythrocyte deformability indices of trained subjects were almost identical to those of sedentary ones, except the hematocrite values which were higher in the trained group than the sedentary group. But erythrocyte aggregation index (M1) and osmotic fragility values were lower in the trained subjects.
Conclusions:
As a result, moderate exercise when living at mid-altitude causes increased hematocrite values probably due to dehydration, as well as lower erythrocyte aggregation and osmotic fragility. But other hematologic parameters and erythrocyte deformability indices do not change significantly. If you live at higher altitudes, your body has long-term adaptation to altitude that allows easily compensate for the lack of oxygen by regular exercising.
To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC233

Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
03/09/2011-07/09/2011
Istanbul, Turkey
INFLUENCE OF ACUTE DAILY MOUNTAIN CLIMBING ON SOME HEMATOLOGICAL PARAMETERS AND RED BLOOD CELL RHEOLOGY IN WINTER
Abstract number: PC234
Dolu¹ Nazan, Basaran² Erdem, Seda Artis¹ A., Aydogan¹ Sami
¹Erciyes University, Faculty of Medicine, Department of Physiology, Kayseri, Turkey
²Erciyes University, Instute of Health Sciences, Department of Physiology, Kayseri, Turkey
Objective:
Accurate reports of some hematological parameters and red blood cell rheology during acute daily mountain climbing activity are sparse. The purpose of this study was to investigate some hematological parameters (erythrocyte, leucocyte number, hematocrit value, hemoglobin concentration together with erythrocyte deformability, aggregation and osmotic fragility, ext) during a daily winter mountain climbing to Erciyes Mountain (3500 m) in Kayseri, Turkey.
Methods:
Seventeen university students, who are regular mountain climbers, participated in this study. They completed their ascent and descent to Erciyes in 24 hours. Hematological parameters, erythrocyte deformability, aggregation and osmotic fragility were determined from blood samples immediately before and after mountain climbing activity.
Results:
When we compared hematological parameters, white blood cells (neutrophil, lymphocyte, basophilic) were statistically increased; eosinophil and hematocrit values were decreased after climbing. We observed a significant decrease in the second measurements of erythrocyte deformability and osmotic fragility compared to the initial measurements. But there were an increase in aggregation indexes in the second measurements.
Conclusions: 
We suggest that differences in white blood cells and red blood cell rheology may result from low temperature in mountains. Physical activity may also change hematological parameters by itself. There was no sign of infectious diseases in the people studied. We need further studies for identify these results.
To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC234